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Plasma contains the most commonly used anticoagulant heparin.

Plasma contains the most commonly used anticoagulant heparin. It acts through a complex it forms with anti-thrombin-III. Anti-thrombin III is a protein that prevents blood clotting.

Serum is the plasma from which the clotting factors have been removed.

Plasma is the translucent part of blood other than RBCs, WBCs, platelets and other cellular components. It helps to clot blood and is composed of 90% water.

Collection of plasma requires a lot of time. It takes around an hour to collect plasma from the body. The blood is drawn from the body with the help of a needle placed in the arm, and the plasma is separated from the red blood cells, white blood cells and platelets.

The serum is done to measure the amount of protein albumin in the blood. When the kidney starts to fail, the albumin starts leaking in the urine. The serum test helps to diagnose liver and kidney abnormalities.

Plasma and serum are derived from the liquid portion of the blood, yet the difference between plasma and serum is quite apparent. Read on to find out how they differ.

Blood is a fluid connective tissue which travels throughout the body by transporting necessary nutrients, oxygen, and metabolic wastes. It is also involved in the regulation of the body’s temperature and the pH levels by interacting with acids and bases.

Blood is primarily composed of RBC (red blood cells), WBC (white blood cells), plasma, and serum. Plasma and serum are the main components of blood and are routinely used in  blood group test  experiments for determining the patient’s blood group.

Plasma and serum can be separated by centrifugation of blood on the basis of weight, size, and density. The serum is the liquid obtained after blood is allowed to clot, whereas plasma is obtained after treating blood with anticoagulation compounds.

Read on to explore the difference between plasma and serum.

Serum and plasma are obtained from the liquid portion of the blood that is obtained when the cells are removed. However, there is striking difference between plasma and serum. Serum is the liquid that remains after the clotting of blood. Whereas, plasma is the liquid that remains when anticoagulant is added to prevent clotting. Following are the important difference between plasma and serum:

Plasma is the medium of the blood, in which different types of blood cells exists. Red blood cells, white blood cells and other components of blood are suspended in plasma.

The serum is the liquid or undiluted part of the blood, which lacks clotting factors. Hence, it is formed after  blood coagulation . The serum helps in the diagnosis of diseases such as blood pressure, sugar, cholesterol, etc.

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A transparent, straw-coloured, liquid portion of the blood.

An undiluted fluid, the extracellular portion of blood.

It is composed of serum and clotting factor.

It is the part of the blood which lacks clotting factor.

It is acquired after centrifuging blood with the anticoagulant.

It is acquired after centrifuging of coagulated blood.

Anticoagulant is required to obtain plasma from the blood sample.

Anticoagulant is not required to separate the serum from the blood sample.

Consists of 55% of the total volume of blood.

Less volume in comparison to plasma.

Comparatively easier and less time is required to separate the plasma from the blood sample.

Difficult to separate serum from the blood sample. It is a time-consuming process.

Consists of 92% water with proteins, salts, lipids, and glucose.

Consists of 90% water with dissolved hormones, proteins, minerals, and carbon dioxide.

Has a long shelf life. It can be preserved up to ten years.

Has a short shelf life. It can be preserved only for a few months.

Plasma is the main medium for excretory product transportation.

An important source of electrolytes.

Cells are freely suspended in plasma.

Cells are attached together by clot formation.